1. 2007年“白血病的耐藥逆轉研究”江蘇省科技進步二等獎
2.2006年“消化道惡性腫瘤患者外周血微轉移檢測及微轉移基因芯片研制及其應用”江蘇省科學技術進步獎三等獎
3. 2006年“中西藥結合增加血液系統腫瘤化療敏感性的基礎與臨床研究”中國中西醫結合學會科技獎三等獎
4.2009 年“多種方法逆轉白血病多藥耐藥的研究及應用”獲教育部科技進步二等獎。
5. 2011 年“基於納米生物技術的腫瘤耐藥識別與逆轉的研究”獲教育部科技進步二等獎。 1.王雪梅，張仁雲，呂剛，吳春惠，李景源，高峰，程堅，陳寶安，付德剛，李小毛，
關之群. 治療白血病的靶向磁性納米藥物及制備方法. 專利號：ZL 2005 1 0040657.1。
2.王雪梅，吳春惠，宋敏，李景源，張仁雲，吳德洪，燕紅，顧忠澤，陳寶安. 有機金
屬碳硼烷靶向納米制劑的制備方法及制成的靶向制劑. 專利號： ZL 2006 1 0096423.3。 1. 國家自然科學基金面上項目：漢防已甲素和角羅西芬逆轉白血病細胞多藥耐藥的機理研究（編號：39970832，研究年限：2000.11－2002.12）已結題
2. 南京市重大課題：非清髓造血幹細胞移植治療白血病（編號：YQ0008，研究年限：2001－2004）已結題
3. 江蘇省衛生廳科技發展基金：生物療法在慢粒ASCT體外凈化作用（編號：H200344，研究年限：2003－2005）已結題
4. 東南大學中大醫院重大課題：非清髓造血幹細胞移植治療血液病（編號：2003YJ02，研究年限：2003－2005）已結題
5. 高等學校博士學科點專項科研基金：***聚合漢防己甲素和化療藥物的磁性納米四氧化三鐵顆粒在逆轉惡性血液病多藥耐藥中的機理研究（編號：20070286042，研究年限：2008－2010）已結題
6. 國家自然基金面上項目：***聚合漢防己甲素和化療藥物的磁性納米四氧化三鐵顆粒在逆轉惡性血液病多藥耐藥中的機理研究（編號：30740062，研究年限：2008－2009）已結題7. 國家自然基金面上項目：磁性納米四氧化三鐵顆粒***聚合柔紅黴素和5－溴漢防己甲素逆轉惡性血液病多藥耐藥的機理研究（編號：30872970，研究年限：2009－2011）已結題8. 國家高技術研究發展計劃（863計劃）子課題：急性白血病的治療（研究年限：2009－2011）已結題
9. 國家高技術研究發展計劃（863計劃）子課題：超靈敏納米多孔生物傳感器件的研究與開發（編號：32007AA022007，研究年限：2009－2011）已結題
10. 國家重點基礎研究發展計劃（973計劃）子課題：基於仿生分子識別的傳感與成像方法研究及其系統設計（編號：2010CB732404，研究年限：2009-2015）在研
11. 國家科技支撐計劃課題（十壹五）子課題：骨髓增生異常綜合征的規範化診斷與治療策略研究（編號：2008BAI61B02，研究年限：2008－2010）已結題
12. 國家自然基金面上項目：化療藥和中藥與轉鐵蛋白納米載體的設計及逆轉白血病耐藥的機制研究（編號：81170492，研究年限：2012－2015）在研
13. 國家高技術研究發展計劃（863計劃）子課題：針對生物標誌物檢測的低成本檢測系統的研制（編號：2012AA022703，研究年限：2012－2016）在研
14. 國家自然基金面上項目：血小板靶向載藥系統的研制及其抗白血病效應的研究（編號：81370673，研究年限：2014－2017）在研
15. 江蘇省科技廳醫學重點項目：江蘇省復發和難治性白血病的規範化治療（編號：BL2014078，研究年限：2014－2017）在研 1.CaiX, Cai X, Wang C, Chen BA*, Hua W, Shen Fet al. Antitumor efficacy of DMSA modified Fe3O4 magneticnanoparticles combined with arsenic trioxide and adriamycin in Raji cells. J Biomed Nanotech2014; 10(2): 251-261.
2.ChangH, Wang X, Shiu KK, Zhu Y, Wang J, Li Q, Chen BA*et al. Layer-by-layer assembly of graphene, Au andpoly(toluidine blue O) films sensor for evaluation of oxidative stress of tumorcells elicited by hydrogen peroxide. Biosensors& Bioelectronics 2013; 41: 789-794.
3.ChengJ, Cheng L, Chen BA*, Xia G, Gao C, Song Het al. Effect of magnetic nanoparticles of Fe3O4 and wogonin onthe reversal of multidrug resistance in K562/A02 cell line. Int J Nanomedicine2012; 7: 2843-2852.
4.FangL, Chen BA,Liu S, Wang R, Hu S, Xia G, Chen BA*et al.Synergistic effect of a combination of nanoparticulate Fe3O4 and gambogic acidon phosphatidylinositol 3-kinase/Akt/Bad pathway of LOVO cells. Int JNanomedicine2012; 7: 4109-4118.
5.JiangN, Zhu X, Zhang H, Wang X, Zhou X, Gu J, Chen BA* et al. The relationship between methylenetetrahydrofolatereductase polymorphism and hematological malignancy. Clin Lab2014; 60(5): 767-774.
6.JinN, Malcherek G, Mani J, Zurleit R, Schmitt A, Chen BAet al. Suppression of cytomegalovirus-specific CD8(+)T cells by everolimus. Leuk Lymphoma 2014; 55(5): 1144-1150.
7.LiK, Chen BA*,Xu L, Feng J, Xia G, Cheng Jet al.Reversal of multidrug resistance by cisplatin-loaded magnetic Fe3O4nanoparticles in A549/DDP lung cancer cells in vitro and in vivo. Int J Nanomedicine 2013; 8: 1867-1877.
8.LiangG, Li J, Sun B, Li S, Lu L, Wang Y, Chen BA*et al. Deep sequencing reveals complex mechanisms ofmicroRNA deregulation in colorectal cancer. IntJ Oncology 2014; 45(2): 603-610.
9.LuX, Zhu A, Cai X, Jia Z, Han W, Ma L, Chen BA*et al. Role of NKG2D in cytokine-induced killer cellsagainst multiple myeloma cells. CancerBio Therapy 2012; 13(8): 623-629.
10.MouY, Hou Y, Chen BA*, Hua Z, Zhang Y, Xie Het al. In vivo migration of dendritic cells labeled with syntheticsuperparamagnetic iron oxide. Int J Nanomedicine 2011; 6: 2633-2640.
11.RenY, Zhang H,Chen BA*, Cheng J, Cai X, Liu Ret al. Multifunctional magnetic Fe3O4 nanoparticles combined withchemotherapy and hyperthermia to overcome multidrug resistance. Int J Nanomedicine2012; 7: 2261-2269.
12.SongG, Gu L, Li J, Tang Z, Liu H, Chen BA* et al. Serum microRNAexpression profiling predict response to R-CHOP treatment in diffuse large Bcell lymphoma patients. Ann Hematol 2014.e-pub ahead of print 2014/05/27
13.WangC, Cai X, Chen BA*, He Z, Chen Z, Cen Jet al. Up-regulation of tissue inhibitor of metalloproteinase-2promotes SHI-1 cell invasion in nude mice. Leuk Lymphoma 2013; 54(12): 2707-2711.
14.WangC, Zhang H, Chen Y, Shi F, Chen BA*. Gambogic acid-loaded magnetic Fe(3)O(4)nanoparticles inhibit Panc-1 pancreatic cancer cell proliferation and migrationby inactivating transcription factor ETS1. Int J Nanomedicine2012; 7: 781-787.
15.Wang F, Zhang W, Guo L, Bao W,Jin N, Liu R, Chen BA*et al. Gambogic acid suppresses hypoxia-inducedhypoxia-inducible factor-1alpha /vascular endothelial growth factor expressionvia inhibiting phosphatidylinositol 3-kinase/Akt/mammalian target protein ofrapamycin pathway in multiple myeloma cells. Cancer Sci2014. e-pub ahead of print 2014/06/04.
16.WangL, Zhang H, Chen BA*, Xia G, Wang S, Cheng Jet al. Effect of magnetic nanoparticleson apoptosis and cell cycle induced by wogonin in Raji cells. Int J Nanomedicine2012; 7: 789-798.
17.WangX, Wang X, Gao S, Zheng Y, Tang M, ChenBA*. A solid-state electrochemiluminescencesensing platform for detection of catechol based on novel luminescent compositenanofibers. Talanta 2013; 107: 127-132.
18.WenJ, Jiang S, Chen Z, Zhao W, Yi Y, Yang R, Chen BA* et al. Apoptosis selectively induced in BEL-7402 cells byfolic acid-modified magnetic nanoparticles combined with 100 Hz magnetic field.Int J Nanomedicine2014; 9: 2043-2050.
19.XuP,Chen BA*,Feng J, Cheng L, Xia G, Li Yet al.Polymorphisms in XPC provide prognostic information in acute myeloid leukemia. IntJ Hematology 2012; 96(4): 450-460.
20.XuP, Li J, Chen BA*, Wang X, Cai X, Jiang Het al. The real-time neurotoxicityanalysis of Fe3O4 nanoparticles combined with daunorubicin for rat brain invivo. JBiomed Nanotechnology 2012; 8(3): 417-423.
21.XuP, Li J, Shi L, Selke M, Chen BA*, Wang X. Synergetic effect of functionalcadmium-tellurium quantum dots conjugated with gambogic acid for HepG2cell-labeling and proliferation inhibition. Int J Nanomedicine2013; 8: 3729-3736.
22.XuY, Wang Y, Li XM, Huang Q, Chen W, Liu R, Chen BA*et al. Study on the release of fenofibrate nanosuspension invitro and its correlation with in situ intestinal and in vivo absorptionkinetics in rats. Drug Dev Indus Pharmacy2014; 40(7): 972-979.
23.YangZ, Chen BA*,Pei X, Shangguan F. Multiplex analysis of tumor multidrug-resistance genesexpression with photonic suspension array. TheAnalyst 2012; 137(14): 3343-3348.
24.ZhangH, Wang C, Chen BA*, Wang X. Daunorubicin-TiO2 nanocompositesas a smart pH-responsive drug delivery system. Int J Nanomedicine2012; 7: 235-242.
25.ZhongY, Wu J, Chen BA*, Ma R, Cao H, Wang Zet al. Investigation and analysis of single nucleotidepolymorphisms in Janus kinase/signal transducer and activator of transcriptiongenes with leukemia. Leuk Lymphoma 2012; 53(6): 1216-1221.
26. Zhang HJ, Chen BA*,Jiang H, Wang CL, Wang HP, Wang XM. A strategy for ZnO nanorod mediatedmulti-mode cancer treatment. Biomaterials. 2011; 32(7):1906-14.
27. Chen BA*, Wu WW, WangXM. Magnetic Iron Oxide Nanoparticles for Tumor-targeted Therapy. Curr CancerDrug Targets 2011; 11(2):184-9.
28. Zhang HJ, Jiang H, Sun FF, Wang HP, Zhao J, Chen BA*, Wang XM. Rapid diagnosis of multidrug resistance in cancerby electrochemical sensor based on carbon nanotubes-drug supramolecularnanocomposites. Biosens Bioelectron. 2011; 26(7):3361-6.
29. Song M, Zhang RR, Dai YY, Gao F, Chi H, Lv G, Chen BA,* Wang XM. The in vitro inhibitionof multidrug resistance by combined nanoparticulate titanium dioxide and UV irradition.Biomaterials. 2006; 27(23):4230-8.
30. Chen BA*, Yin L, ChengJ, Ding JH, Gao C, Sun YY, Zhao G, Wang J, Bao W, Xia GH, Gao F, Wang XM.Effect of D, L-threo-1-phenyl-2-decanoylamino-3-morpholino-1 -propanol andtetrandrine on the reversion of multidrug resistance in K562/A02 cells.Hematology. 2011; 16(1):24-30.
31. Wu WW, Chen BA*, ChengJ, Wang J, Xu WL, Liu LJ, Xia GH, Wei H, Wang XM, Yang M, Yang L, Zhang Y, XuC, Li J. Biocompatibility of Fe3O4/DNR magnetic nanoparticles inthe treatmentof hematologic malignancies. Int J Nanomedicine. 2010; 5:1079-84.
32. Wang J, Chen Y,Chen BA*,Ding JH, Xia GH, Gao C, Cheng J, Jin N, Zhou Y, Li XM, Tang M, Wang XM.Pharmacokinetic parameters and tissue distribution of magnetic Fe(3)O(4) nanoparticlesin mice. Int J Nanomedicine. 2010; 5:861-6.
33. Chen BA*, Mao P, ChengJ, Gao F, Xia GH, Xu WL, Shen HL, Ding JH, Gao C, Sun Q, Chen W, Chen N, LiuLJ, Li XM, Wang XM. Reversal of multidrug resistance by magnetic Fe3O4nanoparticle copolymerizating daunorubicin and MDR1 shRNA expression vector inleukemia cells. Int J Nanomedicine. 2010; 5:437-4.
34. Chen BA*, Jin N, WangJ, Ding JH, Gao C, Cheng J, Xia GH, Gao F, Zhou Y, Chen Y, Zhou G, Li XM, ZhangY, Tang M, Wang XM. The effect of magnetic nanoparticles of Fe(3)O(4) on immunefunction in normal ICR mice. Int J Nanomedicine. 2010; 5:593-9.
35. Zhang HJ, Jiang H, Wang XM,Chen BA*. Reversion of multidrugresistance in tumor by biocompatible nanomaterials. Mini Rev Med Chem. 2010;10(8):737-45.
36. Zhong YJ, Chen BA*,Feng JF, Cheng L, Li Y, Qian J, Ding JH, Gao F, Xia GH, Chen N, Lu Z. Theassociations of Janus kinase-2 (JAK2) A830G polymorphism and the treatment outcomesin patients with acute myeloid leukemia. Leuk Lymphoma. 2010; 51(6):1115-20.
37. Zhu XL, Zhang HJ, Lin Y, Chen P, Min J, Wang Z, Xiao W, Chen BA*. Mechanisms of gambogicacid-induced apoptosis in non-small cell lung cancer cells in relation to transferrinreceptors. J Chemother. 2009; 21(6):666-72.
38. Pei XP, Chen BA*, LiL, Gao F, Jiang Z. Multiplex tumor marker detection with new chemiluminescentimmunoassay based on silica colloidal crystal beads. Analyst. 2010; 135(1):177-81.
39. Chen BA*, Liang YQ, WuWW, Cheng J, Xia GH, Gao F, Ding JH, Gao C, Shao Z, Li G, Chen W, Xu WL, SunXC, Liu LJ, Li XM, Wang XM. Synergistic effect of magnetic nanoparticles ofFe(3)O(4) with gambogic acid on apoptosis of K562 leukemia cells. Int J Nanomedicine.2009; 4:251-9.
40. Cheng J, Wu WW, Chen BA*,Gao F, Xu WL, Gao C, Ding JH, Sun YY, Song HH, Bao W, Sun XC, Xu C, Chen W,Chen N, Liu LJ, Xia GH, Li XM, Wang XM. Effect of magnetic nanoparticles ofFe3O4 and 5-bromotetrandrine on reversal of multidrug resistance in K562/A02leukemic cells. Int J Nanomedicine. 2009; 4:209-16.
41. Pei XP, Zhao Y, Zhao X, Xu H, Chen BA*, Gu ZZ. Multiplex chemiluminescent immunoassay based onsilica colloidal crystal beads. J N N. 2009; 9(11):6320-5.
42. Sun N, Sun XC, Chen BA*,Cheng H, Feng JF, Cheng L, Lu ZH. MRP2 and GSTP1 polymorphisms and chemotherapyresponse in advanced non-small cell lung cancer. Cancer Chemoth Pharm. 2010;65(3):437-46.
43. Li Y, Deng Z, Xuan H, Zhu J, Ding B, Liu X, Chen BA*. Prolonged chronic phase in chronic myelogenous leukemiaafter homoharringtonine therapy. Chin Med J (Engl). 2009;122(12):1413-7.
44. Jiang Z, Chen BA*, XiaGH, Wu Q, Zhang Y, Hong T, Zhang W, Cheng J, Gao F, Liu LJ, Li XM, Wang XM. Thereversal effect of magnetic Fe3O4 nanoparticles loaded with cisplatin onSKOV3/DDP ovarian carcinoma cells. Int J Nanomedicine. 2009; 4:107-14.
45. Chen BA*, Cheng J, WuYN, Gao F, Xu WL, Shen HL, Ding JH, Gao C, Sun Q, Sun XC, Cheng H, Li G, ChenW, Chen N, Liu LJ, Li XM, Wang XM. Reversal of multidrug resistance by magneticFe3O4 nanoparticle copolymerizating daunorubicin and 5-bromotetrandrine inxenograft nude-mice. Int J Nanomedicine. 2009; 4:73-8.
46. Chen BA*, Cheng J,Shen MF, Gao F, Xu WL, Shen HL, Ding JH, Gao C, Sun Q, Sun XC, Cheng H, Li G,Chen W, Chen N, Liu LJ, Li XM, Wang XM. Magnetic nanoparticle of Fe3O4 and5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin inleukemia cells. Int J Nanomedicine. 2009; 4:65-71.
47. Chen BA*, Dai YY, WangXM, Zhang R, Xu WL, Shen HL, Gao F, Sun Q, Deng X, Ding JH, Gao C, Sun Y, ChengJ, Wang J, Zhao G, Chen N. Synergistic effect of the combination of nanoparticulateFe3O4 and Au with daunomycin on K562/A02 cells. Int J Nanomedicine. 2008;3(3):343-50.
48. Chen BA*, Sun Q, WangXM, Gao F, Dai YY, Yin Y, Ding JH, Gao C, Cheng J, Li JY, Sun XC, Chen N, XuWL, Shen HL, Liu D. Reversal in multidrug resistance by magnetic nanoparticleof Fe3O4 loaded with adriamycin and tetrandrine in K562/A02 leukemic cells. IntJ Nanomedicine. 2008; 3(2):277-86.